{"id":110,"date":"2023-05-30T12:15:28","date_gmt":"2023-05-30T12:15:28","guid":{"rendered":"https:\/\/demoweb.company\/huykhanh2\/?p=110"},"modified":"2024-10-10T07:52:36","modified_gmt":"2024-10-10T00:52:36","slug":"quy-trinh-bao-che-vien-nguyen-lieu-mang-mong-2","status":"publish","type":"post","link":"https:\/\/demoweb.company\/fujiseikotech\/2023\/05\/30\/quy-trinh-bao-che-vien-nguyen-lieu-mang-mong-2\/","title":{"rendered":"Tin t\u1ee9c s\u1ed1 02"},"content":{"rendered":"

V\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a thi\u1ebft b\u1ecb b\u00e0o ch\u1ebf, c\u00f4ng ngh\u1ec7 v\u00e0 t\u00e1 d\u01b0\u1ee3c, vi\u00ean gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng ti\u1ebfn b\u1ed9 v\u01b0\u1ee3t b\u1eadc trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y.\u00a0B\u00e0i b\u00e1o n\u00e0y gi\u1edbi thi\u1ec7u ti\u1ebfn b\u1ed9 c\u1ee7a n\u00f3 t\u1eeb c\u00e1c kh\u00eda c\u1ea1nh c\u1ee7a vi\u1ec7c chu\u1ea9n b\u1ecb vi\u00ean v\u00e0 t\u00e1 d\u01b0\u1ee3c.<\/p>\n

1 C\u01a1 ch\u1ebf gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t c\u1ee7a vi\u00ean gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/p>\n

\"\"<\/p>\n

1.1 C\u01a1 ch\u1ebf gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t c\u1ee7a vi\u00ean khung x\u01b0\u01a1ng polyme s\u00e1p v\u00e0 kh\u00f4ng tan. Lo\u1ea1i vi\u00ean khung x\u01b0\u01a1ng n\u00e0y th\u01b0\u1eddng s\u1eed d\u1ee5ng s\u00e1p, ch\u1ea5t b\u00e9o v\u00e0 polyme kh\u00f4ng tan l\u00e0m khung n\u00ean n\u01b0\u1edbc kh\u00f3 x\u00e2m nh\u1eadp v\u00e0o l\u00f5i vi\u00ean. Qu\u00e1 tr\u00ecnh gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t ch\u1ee7 y\u1ebfu l\u00e0 m\u00e0i m\u00f2n-ph\u00e2n t\u00e1n-h\u00f2a tan c\u1ee7a b\u1ec1 m\u1eb7t b\u00ean ngo\u00e0i C\u00e1c y\u1ebfu t\u1ed1 ch\u00ednh \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t l\u00e0 \u0111\u1ed9 h\u00f2a tan c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t, \u0111\u1ed9 x\u1ed1p v\u00e0 k\u00edch th\u01b0\u1edbc l\u1ed7 c\u1ee7a vi\u00ean, v.v.\u00a0B\u1edfi v\u00ec vi\u1ec7c gi\u1ea3i ph\u00f3ng c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00f4ng h\u00f2a tan qu\u00e1 ch\u1eadm, n\u00ean n\u00f3 ph\u00f9 h\u1ee3p h\u01a1n v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c h\u00f2a tan trong n\u01b0\u1edbc.<\/p>\n

1.2 C\u01a1 ch\u1ebf gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t c\u1ee7a m\u00e0ng bao ch\u1ee9a porogen Th\u00f4ng th\u01b0\u1eddng d\u01b0\u1ee3c ch\u1ea5t \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh c\u00e1c l\u00f5i vi\u00ean, sau \u0111\u00f3 \u0111\u01b0\u1ee3c ph\u1ee7 m\u1ed9t l\u1edbp dung d\u1ecbch bao ch\u1ee9a porogen.\u00a0Ch\u1ea5t porogen \u0111\u01b0\u1ee3c g\u1eafn v\u00e0o l\u1edbp ph\u1ee7 v\u00e0 khi l\u1edbp ph\u1ee7 ti\u1ebfp x\u00fac v\u1edbi d\u1ecbch ti\u00eau h\u00f3a, ch\u1ea5t porogen s\u1ebd h\u00f2a tan trong n\u01b0\u1edbc (nh\u01b0ng kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 \u0111\u1ec1u h\u00f2a tan trong n\u01b0\u1edbc v\u00e0 ph\u1ea7n c\u00f2n l\u1ea1i kh\u00f4ng th\u1ec3 ti\u1ebfp x\u00fac v\u1edbi n\u01b0\u1edbc do \u0111\u01b0\u1ee3c bao b\u1ecdc b\u1edfi l\u1edbp m\u00e0ng) h\u00ecnh th\u00e0nh nhi\u1ec1u micropores, n\u01b0\u1edbc th\u1ea5m v\u00e0o l\u00f5i vi\u00ean thu\u1ed1c \u0111\u1ec3 t\u1ea1o th\u00e0nh dung d\u1ecbch b\u00e3o h\u00f2a c\u1ee7a thu\u1ed1c, do \u0111\u00f3 \u0111\u1ea1t \u0111\u01b0\u1ee3c qu\u00e1 tr\u00ecnh gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t g\u1ea7n nh\u01b0 b\u1eb1ng kh\u00f4ng.\u00a0H\u1eb1ng s\u1ed1 t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng thu\u1ed1c kh\u00f4ng theo th\u1ee9 t\u1ef1 Kro [“\u0111i\u1ec1u ki\u1ec7n ch\u00ecm” (\u0111i\u1ec1u ki\u1ec7n ch\u00ecm)] l\u00e0:<\/p>\n

Kro=Dm\/tr=PB.A.CS\/d<\/p>\n

Trong \u0111\u00f3, Dm l\u00e0 li\u1ec1u duy tr\u00ec; tr l\u00e0 th\u1eddi gian l\u01b0u c\u1ee7a ch\u1ebf ph\u1ea9m trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a; PB l\u00e0 h\u1eb1ng s\u1ed1 th\u1ea9m th\u1ea5u c\u1ee7a m\u00e0ng bao; CS l\u00e0 \u0111\u1ed9 h\u00f2a tan c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t; A l\u00e0 di\u1ec7n t\u00edch m\u00e0ng bao c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c vi\u00ean; d l\u00e0 \u0111\u1ed9 d\u00e0y c\u1ee7a m\u00e0ng ph\u1ee7.\u00a0Sau khi d\u1eabn xu\u1ea5t, thu \u0111\u01b0\u1ee3c: r=3Dm\/A (r l\u00e0 b\u00e1n k\u00ednh c\u1ee7a vi\u00ean).\u00a0Do \u0111\u00f3, t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng thu\u1ed1c c\u1ee7a vi\u00ean c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh b\u1eb1ng c\u00e1ch ki\u1ec3m so\u00e1t b\u00e1n k\u00ednh vi\u00ean, \u0111\u1ed9 d\u00e0y l\u1edbp ph\u1ee7 v\u00e0 h\u00e0m l\u01b0\u1ee3ng porogen.\u00a0Trong giai \u0111o\u1ea1n gi\u1ea3i ph\u00f3ng thu\u1ed1c sau n\u00e0y, do l\u01b0\u1ee3ng thu\u1ed1c gi\u1ea3m li\u00ean t\u1ee5c n\u00ean thu\u1ed1c kh\u00f4ng th\u1ec3 \u0111\u1ea1t \u0111\u1ebfn \u0111\u1ed9 b\u00e3o h\u00f2a v\u00e0 t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng thu\u1ed1c cho th\u1ea5y s\u1ef1 gi\u1ea3i ph\u00f3ng thu\u1ed1c theo th\u1ee9 t\u1ef1 \u0111\u1ea7u ti\u00ean khi n\u1ed3ng \u0111\u1ed9 thay \u0111\u1ed5i.<\/p>\n

\"\"<\/p>\n

1.3 C\u01a1 ch\u1ebf gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t c\u1ee7a vi\u00ean nh\u1ef1a d\u1ea1ng vi\u00ean l\u00e0 c\u01a1 ch\u1ebf trao \u0111\u1ed5i d\u01b0\u1ee3c ch\u1ea5t v\u1edbi nh\u1ef1a, v\u00e0 \u0111\u01b0\u1ee3c ph\u1ee7 m\u1ed9t l\u1edbp polyme \u0111\u1ec3 t\u1ea1o th\u00e0nh vi\u00ean.\u00a0Sau khi u\u1ed1ng, c\u00e1c ion trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u00f3 th\u1ec3 \u0111\u1ea9y thu\u1ed1c ra kh\u1ecfi nh\u1ef1a \u0111\u1ec3 ph\u00e1t huy t\u00e1c d\u1ee5ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i c\u1ee7a n\u00f3.<\/p>\n

1.4 C\u01a1 ch\u1ebf gi\u1ea3i ph\u00f3ng thu\u1ed1c d\u1ea1ng vi\u00ean H\u1ec7 th\u1ed1ng gi\u1ea3i ph\u00f3ng thu\u1ed1c xung (pulsatile release system) gi\u1ea3i ph\u00f3ng thu\u1ed1c \u1edf nh\u1eefng ph\u1ea7n c\u1ee5 th\u1ec3 c\u1ee7a \u0111\u01b0\u1eddng ti\u00eau h\u00f3a (ch\u1eb3ng h\u1ea1n nh\u01b0 d\u1ea1 d\u00e0y v\u00e0 ru\u1ed9t k\u1ebft) theo c\u00e1ch \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t v\u1ec1 th\u1eddi gian v\u00e0 ph\u01b0\u01a1ng ph\u00e1p gi\u1ea3i ph\u00f3ng thu\u1ed1c c\u1ee7a n\u00f3 tu\u00e2n theo nh\u1ecbp sinh h\u1ecdc c\u1ee7a c\u01a1 th\u1ec3. c\u01a1 th\u1ec3 con ng\u01b0\u1eddi. m\u1ed9t l\u0129nh v\u1ef1c m\u1edbi c\u1ee7a .\u00a0C\u00e1c vi\u00ean gi\u1ea3i ph\u00f3ng xung c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 h\u1ec7 th\u1ed1ng n\u1ed5 ki\u1ec3m so\u00e1t th\u1eddi gian (TES), \u0111\u01b0\u1ee3c chia th\u00e0nh b\u1ed1n l\u1edbp t\u1eeb trong ra ngo\u00e0i: l\u00f5i vi\u00ean-l\u1edbp thu\u1ed1c-l\u1edbp m\u1edf r\u1ed9ng-m\u00e0ng ph\u1ee7 b\u00ean ngo\u00e0i polymer kh\u00f4ng tan trong n\u01b0\u1edbc.\u00a0\u0110\u1ed9 \u1ea9m x\u00e2m nh\u1eadp v\u00e0o h\u1ec7 th\u1ed1ng th\u00f4ng qua l\u1edbp ph\u1ee7 b\u00ean ngo\u00e0i v\u00e0 ti\u1ebfp x\u00fac v\u1edbi l\u1edbp tr\u01b0\u01a1ng n\u1edf.Khi l\u1ef1c tr\u01b0\u01a1ng n\u1edf c\u1ee7a l\u1edbp tr\u01b0\u01a1ng n\u1edf hydrat h\u00f3a v\u01b0\u1ee3t qu\u00e1 \u0111\u1ed9 b\u1ec1n k\u00e9o c\u1ee7a l\u1edbp ph\u1ee7 b\u00ean ngo\u00e0i, l\u1edbp ph\u1ee7 b\u1eaft \u0111\u1ea7u v\u1ee1 ra, do \u0111\u00f3 k\u00edch ho\u1ea1t gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t.\u00a0Th\u1eddi gian tr\u1ec5 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1eb1ng c\u00e1ch thay \u0111\u1ed5i \u0111\u1ed9 d\u00e0y c\u1ee7a l\u1edbp ph\u1ee7 b\u00ean ngo\u00e0i.<\/p>\n","protected":false},"excerpt":{"rendered":"

V\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a thi\u1ebft b\u1ecb b\u00e0o ch\u1ebf, c\u00f4ng ngh\u1ec7 v\u00e0 t\u00e1 d\u01b0\u1ee3c, vi\u00ean gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng ti\u1ebfn b\u1ed9 v\u01b0\u1ee3t b\u1eadc trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y.\u00a0B\u00e0i b\u00e1o n\u00e0y gi\u1edbi thi\u1ec7u ti\u1ebfn b\u1ed9 c\u1ee7a n\u00f3 t\u1eeb c\u00e1c kh\u00eda c\u1ea1nh c\u1ee7a vi\u1ec7c chu\u1ea9n b\u1ecb vi\u00ean v\u00e0 t\u00e1 d\u01b0\u1ee3c. 1 C\u01a1 ch\u1ebf…<\/p>\n","protected":false},"author":1,"featured_media":103,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,26],"tags":[],"class_list":["post-110","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc","category-tu-van"],"_links":{"self":[{"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/posts\/110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/comments?post=110"}],"version-history":[{"count":1,"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/posts\/110\/revisions"}],"predecessor-version":[{"id":458,"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/posts\/110\/revisions\/458"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/media\/103"}],"wp:attachment":[{"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/media?parent=110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/categories?post=110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/demoweb.company\/fujiseikotech\/wp-json\/wp\/v2\/tags?post=110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}